Preferred Label : DLEC1 wt Allele;
NCIt synonyms : DLC1; DLEC1; F56; Deleted in Lung and Esophageal Cancer 1 wt Allele; DLC-1; CFAP81;
NCIt definition : Human DLEC1 wild-type allele is located within 3p22-p21.3 and is approximately 261
kb in length. This allele, which encodes deleted in lung and esophageal cancer 1 protein,
plays a role in tumor suppression. This allele is frequently deleted or abberantly
expressed in several cancers.;
NCIt note : DLEC1 Gene contains 37 exons that encode numerous alternatively spliced, widely expressed
6-8-kb mRNAs (DLEC1-N, -L, -S). DLEC1-N1 and -N2 contain all 37 exons and encode a
full-length 1755-amino acid 195.8-kD DLEC1 Protein, a likely negative regulator of
cell proliferation. DLEC1-S1, -S2, and -S3 lack exons 11, 13, or 36 and encode frame-shifted
protein. DLEC1-L1 and -L2 include all or part of intron 13 and encode prematurely
truncated proteins. DLC1 expression appears to suppress growth of some cancer cell
lines. Aberrant transcription may be involved in carcinogenesis of the lung, esophagus,
and kidney.;
GenBank Accession Number : NM_005106;
Origin ID : C54432;
UMLS CUI : C1705128;
OMIM relation
- Semantic type(s)
- gene_associated_with_disease
- gene_found_in_organism
- gene_has_physical_location
- gene_in_chromosomal_location
- gene_plays_role_in_process
