NCIt synonyms : BTZ; MLN51; Cancer Susceptibility Candidate 3 wt Allele; Barentsz, Drosophila, Homolog of Gene; MLN51 wt Allele;
NCIt definition : Human CASC3 wild-type allele is located within 17q11-q21.3 and is approximately 32
kb in length. This allele, which encodes protein CASC3, plays a role in the regulation
of nonsense-mediated messenger RNA decay.;
NCIt note : The CASC3 gene product is a subunit of the exon junction complex. This complex controls
nonsense-mediated mRNA decay, which is a mechanism that degrades messenger RNAs with
premature translation termination codons. (OMIM);