NCIt definition : Human KISS1 wild-type allele is located in the vicinity of 1q32 and is approximately
6 kb in length. This allele, which encodes metastasis-suppressor KiSS-1 protein, plays
a role in metastasis suppression.;
NCIt note : KISS1 is expressed as a 1 kb mRNA in normal placenta tissue and as smaller transcripts
at low levels in pancreas and kidney. KISS1 may suppress metastasis without affecting
tumorigenicity. Placental Metastin, a truncated C-terminally amidated peptide form
of KISS1, with 54 amino acid residues, is an endogenous ligand of orphan GPR54 (a
GPCR) and appears to inhibit chemotaxis and metastasis. The gene product of KISS1
may regulate events downstream of cell-matrix adhesion, and may involve cytoskeletal
reorganization.;