" /> AFF1 wt Allele - CISMeF





Preferred Label : AFF1 wt Allele;

NCIt synonyms : MLL/AF4; MGC134969; Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated to, 2 Gene; AF4/FMR2 Family Member 1 wt Allele; AF4-MLL; MLLT2; AF-4; PBM1; AF4; AF4/FMR2 Family, Member 1 Gene; MLLT2 wt Allele;

NCIt definition : Human AFF1 wild-type allele is located in the vicinity of 4q21 and is approximately 206 kb in length. This allele, which encodes AF4/FMR2 family member 1 protein, is involved in the modulation of transcription by RNA polymerase II. Several acute leukemias are associated with the translocation t(4;11)(q21;q23) of the gene and the MLL gene.;

NCIt note : Disease entities associated with translocation of the AFF1 gene include: typically CD19 B-cell acute lymphocytic leukemia, biphenotypic acute leukemias, acute nonlymphocytic leukemia; congenital leukemias and treatment-related leukemias.;

GenBank Accession Number : NM_005935;

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12/05/2024


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