NCIt definition : Human CYP2D6 wild-type allele is located in the vicinity of 22q13.1 and is approximately
4 kb in length. This allele, which encodes cytochrome P450 2D6 protein, plays a role
in the metabolism of drugs and xenobiotics. The CYP2D6 gene is highly polymorphic
in the human population. Many allelic variants of this gene contribute to the poor
metabolizer phenotype. Conversely, two variant alleles of this gene contribute to
the rapid metabolizer phenotype. Individuals who are poor metabolizers of cytochrome
P450 2D6 substrates are at increased risk for the development of pesticide-induced
somatic Parkinson's disease.;
NCIt note : The poor metabolizer phenotype is characterized by the inability to use cytochrome
P450-dependent metabolic pathways for drug elimination. The rapid metabolizer phenotype
is characterized by the enhanced ability to use cytochrome P450-dependent metabolic
pathways for drug elimination.;