NCIt definition : A human monoclonal antibody directed against the insulin-like growth factor type I
receptor (IGF1R) with potential antineoplastic activity. Figitumumab selectively binds
to IGF1R, preventing insulin-like growth factor type 1 (IGF1) from binding to the
receptor and subsequent receptor autophosphorylation. Inhibition of IGF1R autophosphorylation
may result in a reduction in receptor expression on tumor cells that express IGF1R,
a reduction in the anti-apoptotic effect of IGF, and inhibition of tumor growth. IGF1R
is a receptor tyrosine kinase expressed on most tumor cells and is involved in mitogenesis,
angiogenesis, and tumor cell survival.;
UNII : VE267FC2UB;
CAS number : 943453-46-1;
Molecule name : CP-751,871; CP-751871; CP 751,871;