ING1 wt Allele

Preferred Label : ING1 wt Allele;

NCIt synonyms : p33ING1; Inhibitor of Growth Family, Member 1 wt Allele;

NCIt definition : Human ING1 wild-type allele is located within 13q34 and is approximately 8 kb in length. This allele, which encodes inhibitor of growth protein 1, plays a role in the induction of p53-mediated apoptosis and modulation of p53-dependent transcriptional activation which results in the inhibition of cell growth. Certain allelic variants of the ING1 gene are associated with the development of squamous cell carcinoma of the head and neck. Expression of the ING1 gene is down-regulated in several types of cancer such as breast cancer, gastric cancer, neuroblastoma and non-small cell lung cancer.;

NCIt note : The ING1 gene is a candidate tumor suppressor gene. This gene produces multiple mRNA transcripts via alternative splicing which, in turn, encode distinct protein isoforms.;

GenBank Accession Number : NM_005537;

Details

Origin ID

C52083;

UMLS CUI

C1708444;

OMIM relation
- Inhibitor of growth 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_associated_with_disease
- Head and Neck Squamous Cell Carcinoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 13: 110163084-110171422 [NCIt concept]
gene_in_chromosomal_location
- 13q34 [NCIt concept]
gene_plays_role_in_process
- Apoptosis [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Tumor Suppression [NCIt concept]

Keyword's position in hierarchy(ies) :

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