" /> DEK wt Allele - CISMeF





Preferred Label : DEK wt Allele;

NCIt synonyms : DEK Oncogene; D6S231E; DEK Proto-Oncogene wt Allele; DEK Oncogene (DNA Binding) Gene;

NCIt definition : Human DEK wild-type allele is located within 6p23 and is approximately 40 kb in length. This allele, which encodes protein DEK, plays a role in both 3' splice site discrimination and intron removal during mRNA formation. Translocation of the DEK gene is associated with acute myeloid leukemia. This gene is overexpressed in certain types of cancer such as bladder cancer, colon cancer, larynx cancer, and melanoma.;

NCIt note : In a subset of acute myeloid leukemia, the DEK gene undergoes a t(6;9)(p23;q34) translocation to form a fusion gene with the NUP214 gene.;

GenBank Accession Number : X64229;

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12/05/2024


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