GCLM wt Allele

Preferred Label : GCLM wt Allele;

NCIt synonyms : Gamma-Glutamylcysteine Synthetase, Regulatory Subunit Gene; GLCLR; RP4-561L24.2; Glutamate-Cysteine Ligase Modifier Subunit wt Allele; Glutamate-Cysteine Ligase (Gamma-Glutamylcysteine Synthetase), Regulatory (30.8kD) Gene; Glutamate-Cysteine Ligase, Modifier Subunit Gene; Glutamate-Cysteine Ligase, Regulatory Gene;

NCIt definition : Human GCLM wild-type allele is located in the vicinity of 1p22.1 and is approximately 21 kb in length. This allele, which encodes glutamate-cysteine ligase regulatory subunit protein, plays a role in glutathione biosynthesis. An allelic variant of the GCLM gene is associated with susceptibility to myocardial infarction.;

NCIt note : Overexpression of the GCLM gene has been shown to be correlated with resistance to the chemotherapeutic agent cisplatin in small cell lung cancer xenografts in vivo.;

GenBank Accession Number : NM_002061;

Details

Origin ID

C52035;

UMLS CUI

C1704696;

OMIM relation
- Glutamate-cysteine ligase, modifier subunit [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Myocardial Infarction [NCIt concept]
gene_has_physical_location
- 1: 94086987-94066034 [NCIt concept]
gene_in_chromosomal_location
- 1p22.1 [NCIt concept]
gene_is_element_in_pathway
- Alanine, Aspartate and Glutamate Metabolism Pathway [NCIt concept]
- Glutathione Metabolism Pathway [NCIt concept]
gene_plays_role_in_process
- Detoxification [NCIt concept]
- Peptide Metabolism [NCIt concept]

Keyword's position in hierarchy(ies) :

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