Preferred Label : VEGFA wt Allele;
NCIt synonyms : VEGF-A; VPF; Vascular Endothelial Growth Factor A wt Allele; MGC70609; VEGF; VEGF wt Allele;
NCIt definition : Human VEGFA wild-type allele is located within 6p12 and is approximately 16 kb in
length. This allele, which encodes vascular endothelial growth factor A protein, plays
a role in several processes related to vasculature function, including angiogenesis.
The allele is also involved in endothelial cell growth cell migration and apoptotic
inhibition.;
NCIt note : The VEGF Gene (PDGF/VEGF Family) at 6p12 encodes seven alternatively spliced isoforms
of Vascular Endothelial Growth Factor: VEGF206, VEGF189, VEGF183, VEGF165/VEGF, VEGF148,
VEGF145, and VEGF121. This gene is regulated by growth factors, cytokines, gonadotropins,
nitric oxide, hypoxia, and hypoglycemia. Expression is induced by hypoxia and E2 regulates
transcription through a variant upstream ERE.; Isoforms: VEGF206, VEGF189, VEGF183, VEGF165/VEGF, VEGF148, VEGF145, VEGF121;
GenBank Accession Number : NM_003376;
Origin ID : C52018;
UMLS CUI : C2349086;
OMIM relation
- Semantic type(s)
- concept_is_in_subset
- gene_associated_with_disease
- gene_found_in_organism
- gene_in_chromosomal_location
- gene_is_element_in_pathway
- gene_plays_role_in_process
