Preferred Label : LTB wt Allele;
NCIt synonyms : DAAP-90L16.4; Lymphotoxin Beta Gene; Lymphotoxin B Gene; TNFSF3; Tumor Necrosis Factor C Gene; p33; TNFC; Lymphotoxin Beta (TNF Superfamily, Member 3) wt Allele;
NCIt definition : Human LTB wild-type allele is located in the vicinity of 6p21.3 and is approximately
5 kb in length. This allele, which encodes lymphotoxin-beta protein, plays a role
in inflammatory responses and is involved in the normal development of lymphoid tissue.;
NCIt note : Human LTB Gene (TNF family) at 6p21.3 encodes TNFC, a 33 kD type II membrane glycoprotein
with homology to TNF Alpha, TNF Beta, and CD40 ligand. Between C4 and HLA-B in the
MHC region, TNFC resides just centromeric to TNFA, which is just centromeric to TNFB.
These three similar genes lie about 200 kb from HLA-B. TNFC is flanked by B144 and
1C7 on one side and by IKBL and BAT1 on the other. TNFC transcribes telomerically,
TNFB and TNFA centromerically. Two isoforms are produced by alternative splicing.
Involved in immunologic cell-cell contact reactions, TNFC associates as a membrane
anchor in a heterotrimeric complex with TNFB on activated T, B, and LAK cells.;
GenBank Accession Number : NM_009588;
Origin ID : C51511;
UMLS CUI : C1705747;
OMIM relation
- Semantic type(s)
- concept_is_in_subset
- gene_found_in_organism
- gene_has_physical_location
- gene_in_chromosomal_location
- gene_is_element_in_pathway
- gene_plays_role_in_process
