" /> WFDC2 wt Allele - CISMeF





Preferred Label : WFDC2 wt Allele;

NCIt synonyms : WAP5; WAP Four-Disulfide Core Domain 2 wt Allele; dJ461P17.6; HE4; EDDM4; Epididymis-Specific, Whey-Acidic Protein Type, Four-Disulfide Core Gene;

NCIt definition : Human WFDC2 wild-type allele is located within 20q12-q13.2 and is approximately 12 kb in length. This allele, which encodes WAP four-disulfide core domain protein 2, is putatively involved in the innate immune response of the lung, nasal and oral epithelia. WFDC2 gene expression is up-regulated in certain cancers such as lung adenocarcinomas, pancreatic carcinomas and ovarian serous carcinomas.;

NCIt note : Expression of the WFDC2 gene has been shown to be down-regulated in prostate cancer. This gene produces five transcript variants which encode distinct protein isoforms.;

GenBank Accession Number : NM_006103;

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12/05/2024


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