NCIt synonyms : Serine (or Cysteine) Proteinase Inhibitor, Clade I (Pancpin), Member 2 wt Allele; TSA2004; SERPIN12; PI14; MEPI; PANCPIN;
NCIt definition : Human SERPINI2 wild-type allele is located within 3q26.1-q26.2 and is approximately
32 kb in length. This allele, which encodes serpin I2 protein, is involved in the
inhibition of serine protease enzymes.;
NCIt note : The SERPINI2 gene has been shown to be down-regulated in pancreatic cancer cell lines
compared to normal pancreatic tissues. Expression of this gene has been shown to be
abolished in breast carcinomas. The SERPINI2 gene is suggested to be a candidate tumor
suppressor gene which prevents the development or progression of cancer.;
OMIM relation