Tegafur - CISMeF

Preferred Label : Tegafur;

NCIt synonyms : 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione; N1-(2'-Furanidyl)-5-fluorouracil; FT; 5-Fluoro-1-(tetrahydro-2-furyl)-uracil; 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4-(1H,3H)-pyrimidinedione;

NCIt related terms : Ftorafur; Uracil, 5-fluoro-1-(tetrahydro-2-furyl)-;

NCIt definition : A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called antimetabolites.;

UNII : 1548R74NSZ;

InChIKey : WFWLQNSHRPWKFK-UHFFFAOYSA-N;

CAS number : 17902-23-7;

Drug name : Sinoflurol; Citofur; Lamar; Sunfural; Florafur; Tefsiel; Ftoralon; Furofutran; Neberk; Furafluor; Fluorofur; Ftorafur; Fulaid; Utefos; Riol; Ftoral; Coparogin; Fulfeel; Nitobanil; Exonal; Futraful; Lifril; Fental;

Molecule name : FT-207; WR-220066; MJF-12264;

Chemical formula : C8H9FN2O3;

NSC code : 148958;

Codes from synonyms : 00543; CDR0000045201; NSC0148958; CDR0000549432;

Details

Origin ID

C513;

UMLS CUI

C0016778;

Automatic exact mappings (from CISMeF team)
- Fluoride [LOINC component]
- Foot (qualifier value) [SNOMED CT concept]
- fluorides [MeSH Descriptor]
False automatic mappings
- Fluoride [SMS substance]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 5-fluoro-1-(tetrahydro-2-furyl)uracil [Substance BNPC]
- Product containing tegafur (medicinal product) [SNOMED CT concept]
- Tegafur [ICD-11 Extension code]
- Tegafur (substance) [SNOMED CT concept]
- tegafur [ATC Code]
- tegafur [MeSH concept]
- tegafur [MeSH Descriptor]
Validated automatic mappings to BTNT
- tegafur [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- ACFTOR-BCG Regimen [NCIt concept]
- BCG/Cyclophosphamide/Doxorubicin/Tegafur [NCIt concept]
- Chlorodihydroxypyridine/Potassium Oxonate/Tegafur [NCIt concept]
- Cisplatin/Cyclophosphamide/Doxorubicin/Tegafur [NCIt concept]
- Cyclophosphamide/Doxorubicin/Fluorouracil/Tegafur/Tamoxifen [NCIt concept]
- Cyclophosphamide/Doxorubicin/Uracil/Tegafur/Tamoxifen [NCIt concept]
- Doxorubicin/Mitomycin/Tegafur Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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