MATK wt Allele

Preferred Label : MATK wt Allele;

NCIt synonyms : DKFZp434N1212; CTK; MGC2101; MGC1708; HYL; HHYLTK; Lsk; Megakaryocyte-Associated Tyrosine Kinase wt Allele; CHK;

NCIt definition : Human MATK wild-type allele is located in the vicinity of 19p13.3 and is approximately 24 kb in length. This allele, which encodes megakaryocyte-associated tyrosine-protein kinase protein, plays a role in the inactivation of Src-family kinases.;

NCIt note : The MATK gene is expressed at high levels in megakaryocytes and lower levels in adult brain. This gene undergoes alternative splicing to yield three transcript variants and three corresponding protein isoforms. Megakaryocyte-associated tyrosine-protein kinase protein decreases CXCR4-mediated breast cancer cell motility and migration via down-regulation of this chemokine receptor gene.;

GenBank Accession Number : NM_002378;

Details

Origin ID

C51090;

UMLS CUI

C1705672;

OMIM relation
- Megakaryoctye-associated tyrosine kinase [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 19p13.3 [NCIt concept]
gene_is_element_in_pathway
- Neurotrophin Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Megakaryocyte Differentiation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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