GSTT1 wt Allele

Preferred Label : GSTT1 wt Allele;

NCIt synonyms : Glutathione S-Transferase Theta 1 wt Allele;

NCIt definition : Human GSTT1 wild-type allele is located in the vicinity of 22q11.23 and is approximately 8 kb in length. This allele, which encodes glutathione S-transferase theta-1 protein, is involved in the conjugation of reduced glutathione with both endogenous and exogenous hydrophobic electrophilic compounds. The GSTT1 null genotype is associated with an increased risk for the development of cancer.;

GenBank Accession Number : NM_000853;

Details

Origin ID

C51041;

UMLS CUI

C1708158;

OMIM relation
- Glutathione s-transferase, theta-1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 22: 22708785-22700695 [NCIt concept]
gene_in_chromosomal_location
- 22q11.23 [NCIt concept]
gene_is_element_in_pathway
- Drug Metabolism by Cytochrome P450 Pathway [NCIt concept]
- Glutathione Metabolism Pathway [NCIt concept]
- Metabolism of Xenobiotics by Cytochrome P450 Pathway [NCIt concept]
gene_plays_role_in_process
- Detoxification [NCIt concept]

Keyword's position in hierarchy(ies) :

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