NCIt synonyms : RP11-262K24.2; MutS Homolog 4 wt Allele; MutS (E. Coli) Homolog 4 Gene; MutS, E. coli, Homolog of, 4 Gene; MutS Homolog 4 (E. coli) Gene;
NCIt definition : Human MSH4 wild-type allele is located within 1p31 and is approximately 116 kb in
length. This allele, which encodes MutS protein homolog 4 protein, is involved in
meiotic recombination.;
NCIt note : MSH4 gene encodes a protein that belongs to the DNA mismatch repair mutS family and
is involved in meiotic recombination. It is required for reciprocal recombination
and proper segregation of homologous chromosomes at meiosis. The human MSH4 transcripts
are detectable only in testis and in ovary with a lower level of expression.;