RRM2 wt Allele

Preferred Label : RRM2 wt Allele;

NCIt synonyms : Ribonucleotide Reductase M2 Polypeptide Gene; R2 Gene; RR2 Gene; Ribonucleoside-Diphosphate Reductase M2 Chain Gene; Ribonucleotide Reductase Small Chain Gene; RR2M; RIR2; Ribonucleotide Reductase M2 wt Allele;

NCIt definition : Human RRM2 wild-type allele is located within 2p25-p24 and is approximately 8 kb in length. This allele, which encodes ribonucleoside-diphosphate reductase M2 subunit protein, plays a role in the reduction of ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in dividing cells.;

NCIt note : Overexpression of the RRM2 gene is associated with resistance to a variety of chemotherapeutic agents.;

GenBank Accession Number : NM_001034;

Details

Origin ID

C50930;

UMLS CUI

C1709828;

OMIM relation
- Ribonucleotide reductase regulatory subunit m2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 2p25-p24 [NCIt concept]
gene_is_element_in_pathway
- E2F Transcription Factor Pathway [NCIt concept]
- Glutathione Metabolism Pathway [NCIt concept]
- Purine Metabolism Pathway [NCIt concept]
- Pyrimidine Metabolism Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_plays_role_in_process
- Cell Proliferation [NCIt concept]
- DNA Replication [NCIt concept]
- DNA Synthesis [NCIt concept]
- Drug Resistance Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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