" /> DHFR wt Allele - CISMeF





Preferred Label : DHFR wt Allele;

NCIt synonyms : Dihydrofolate Reductase wt Allele;

NCIt definition : Human DHFR wild-type allele is located within 5q11.2-q13.2 and is approximately 29 kb in length. This allele, which encodes dihydrofolate reductase protein, plays a role in the de novo synthesis of glycine, purines and thymidylic acid. It is also involved in the regulation of endothelial nitric oxide levels. Allelic variants of the DHFR gene are associated with malaria and megaloblastic amemia.;

NCIt note : Dihydrofolate reductase is a drug target. Specific mutations in the DHFR gene confer cellular resistance to the chemotherapeutic agent methotrexate.;

GenBank Accession Number : NM_000791;

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Keyword's position in hierarchy(ies) : arborescence

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20/05/2024


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