TMPRSS2 wt Allele

Preferred Label : TMPRSS2 wt Allele;

NCIt synonyms : PRSS10; Epitheliasin Gene; Transmembrane Protease, Serine 2 Gene; PP9284; Transmembrane Serine Protease 2 wt Allele;

NCIt definition : Human TMPRSS2 wild-type allele is located in the vicinity of 21q22.3 and is approximately 51 kb in length. This allele, which encodes transmembrane protease, serine 2 protein, plays a role in G-protein-coupled-receptor activation. The TMPRSS2 gene is overexpressed in neoplastic prostate epithelium. It has also been shown to be translocated in prostate tumors wherein certain fusion genes are formed with other transcription factor genes.;

GenBank Accession Number : NM_005656;

Details

Origin ID

C50377;

UMLS CUI

C1710301;

OMIM relation
- Transmembrane serine protease 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Prostate Carcinoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 21q22.3 [NCIt concept]
gene_is_element_in_pathway
- Androgen Receptor Regulation Pathway [NCIt concept]
- Coregulation Pathway for Androgen Receptor Activity [NCIt concept]
gene_plays_role_in_process
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients