Fluconazole - CISMeF

Preferred Label : Fluconazole;

NCIt synonyms : alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol;

NCIt definition : A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition.;

Alternative definition : NCI-GLOSS: A drug that treats infections caused by fungi.;

UNII : 8VZV102JFY;

InChIKey : RFHAOTPXVQNOHP-UHFFFAOYSA-N;

CAS number : 86386-73-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 86386-73-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Diflucan;

Chemical formula : C13H12F2N6O;

ChEBI ID : CHEBI:46081;

Codes from synonyms : CDR0000045320; 223;

Details

Origin ID

C500;

UMLS CUI

C0016277;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Fluconazole [ICD-11 Extension code]
- Fluconazole [LOINC component]
- Fluconazole (substance) [SNOMED CT concept]
- Product containing fluconazole (medicinal product) [SNOMED CT concept]
- fluconazole [ATC Code]
- fluconazole [ATC Code]
- fluconazole [Substance BNPC]
- fluconazole [SNOMED Notion]
- fluconazole [MeSH concept]
- fluconazole [MeSH Descriptor]
Validated automatic mappings to BTNT
- fluconazole [ATC Code]
- fluconazole [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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