TCTA wt Allele

Preferred Label : TCTA wt Allele;

NCIt synonyms : T-Cell Leukemia Translocation Altered wt Allele; T-Cell Leukemia Translocation-Associated Gene;

NCIt definition : Human TCTA wild-type allele is located within 3p21 and is approximately 4 kb in length. This allele encodes T-cell leukemia translocation-associated gene protein. The TCTA gene has been shown exhibit a t(14;21)(q11. 2;q22) chromosomal translocation in T-cell acute lymphoblastic leukemia, resulting in activation of BHLHB1 gene expression. This alteration leads to a leukemogenic effect via the functional inactivation of repressor proteins.;

GenBank Accession Number : NM_022171;

Details

Origin ID

C49429;

UMLS CUI

C1710285;

Automatic exact mappings (from CISMeF team)
- T-cell leukemia translocation-associated gene [OMIM gene]
OMIM relation
- T-cell leukemia translocation-associated gene [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_associated_with_disease
- Leukemia [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 3p21 [NCIt concept]
gene_plays_role_in_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Tumor Suppression [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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