XAF1 wt Allele

Preferred Label : XAF1 wt Allele;

NCIt synonyms : HSXIAPAF1; XIAP Associated Factor 1 wt Allele; BIRC4 Binding Protein Gene; XIAPAF1; BIRC4BP; XIAP-Associated Factor 1 Gene;

NCIt definition : Human XAF1 is located in the vicinity of 17p13.2 and is approximately 20 kb in length. This gene, which encodes XIAP-associated factor 1 protein, is involved in apoptosis and caspase inhibition.;

NCIt note : HSXIAPAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells. This is associated with the nuclear redistribution of XIAP, as cytoplasmic XAF1 appears to antagonize nuclear XIAP inhibition of CASP3 activity.;

GenBank Accession Number : NM_017523;

Details

Origin ID

C49394;

UMLS CUI

C1705708;

OMIM relation
- Xiap-associated factor 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 17: 6599880-6619690 [NCIt concept]
gene_in_chromosomal_location
- 17p13.2 [NCIt concept]
gene_plays_role_in_process
- Apoptosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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