EPHX1 wt Allele

Preferred Label : EPHX1 wt Allele;

NCIt synonyms : Epoxide Hydrolase 1, Microsomal (Xenobiotic) wt Allele; EPHX; EPOX; MEH;

NCIt definition : Human EPHX1 wild-type allele is located in the vicinity of 1q42.1 and is approximately 35 kb in length. This allele, which encodes epoxide hydrolase 1 protein, is involved in the metabolism of both arene and aliphatic epoxides. Certain allelic variants of the EPHX1 gene confer susceptibility to lymphoproliferative disorders. Specific inherited defects in this gene also cause familial hypercholanemia. An EPHX1 low-activity genotype is associated with decreased risk of lung cancer.;

GenBank Accession Number : NM_000120;

Details

Origin ID

C49357;

UMLS CUI

C1705462;

OMIM relation
- Epoxide hydrolase 1, microsomal [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 1: 222319711-222339996 [NCIt concept]
gene_in_chromosomal_location
- 1q42.1 [NCIt concept]
gene_is_element_in_pathway
- Drug Metabolism by Cytochrome P450 Pathway [NCIt concept]
gene_plays_role_in_process
- Detoxification [NCIt concept]
- Hydrolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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