NCIt definition : Any diuretic agent that produces diuresis without increasing potassium excretion.
Potassium sparing diuretics are generally either aldosterone antagonists and thus
prevent the aldosterone-mediated promotion of sodium and water retention, or are epithelial
sodium channel blockers and prevent the exchange of potassium for sodium in the distal
convoluted tubule. These agents cause diuresis without increasing potassium secretion
and thus do not cause hypokalemia.;