sodium channel blockers

Preferred Label : sodium channel blockers;

MeSH definition : A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.;

MeSH synonym : channel blockers, sodium; sodium channel inhibitors; channel inhibitors, sodium; inhibitors, sodium channel; Sodium Channel Inhibitor; Channel Inhibitor, Sodium; Inhibitor, Sodium Channel; Sodium Channel Blocker; Blocker, Sodium Channel; Channel Blocker, Sodium;

MeSH annotation : coordinate with DIURETICS if pertinent; DF: NA CHANNEL BLOCK; coordinate with DIURETICS if pertinent;

Wikipedia link : https://en.wikipedia.org/wiki/Sodium channel blockers;

Is substance : O;

action pharmacologique : O;

Details

Origin ID

D026941;

UMLS CUI

C0872271;

ATC code(s)
- low-ceiling diuretics and potassium-sparing agents [ATC Code]
- other potassium-sparing agents [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Substance with sodium channel blocker mechanism of action (substance) [SNOMED CT concept]
False automatic mappings
- Potassium-sparing diuretic (substance) [SNOMED CT concept]
Indexing information
- 2-(2-fluoro-3-(((3-fluorobenzyl)oxy)-8-azabicyclo(3.2.1)oct-8-yl)propyl)-4,5-dimethyl-2,4-dihydro-3H-1,2,4-triazol-3-one [MeSH Supplementary Concept]
- CFM6104 [MeSH Supplementary Concept]
- cymatherelactone [MeSH Supplementary Concept]
MeSH Descriptor(s) used for indexing
- degenerin sodium channels [MeSH Descriptor]
- sodium channels [MeSH Descriptor]
Record concept(s)
- sodium channel blockers [MeSH concept]
See also
- anti-arrhythmia agents [MeSH Descriptor]
See also (suggested by CISMeF)
- sodium channels [MeSH Descriptor]
See also inter- (CISMeF)
- Potassium-Sparing Diuretic [NCIt concept]
- Potassium-sparing diuretic (product) [Inactive SNOMED CT concept]
- Sodium channel blocker (disposition) [SNOMED CT concept]
- potassium sparing diuretics [CISMeF Querying Strategy]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
Substance(s)
- 1,3-bis(4-sec-butylphenyl)-4,5-dihydroimidazol-2-ylamine [MeSH Supplementary Concept]
- 1,3-bis(4-sec-butylphenyl)tetrahydropyrimidin-2-ylideneamine [MeSH Supplementary Concept]
- 2,4-diamino-5-(2,3-dichlorophenyl)-6-fluoromethylpyrimidine [MeSH Supplementary Concept]
- AM 36 [MeSH Supplementary Concept]
- BIIB 513 [MeSH Supplementary Concept]
- CNS 1237 [MeSH Supplementary Concept]
- Lamotrigine [MeSH Descriptor]
- N,N-(diphenyl)-4-ureido-5,7-dichloro-2-carboxyquinoline [MeSH Supplementary Concept]
- N-(2,6-dimethylphenyl)-2-pyrrolidinecarboxamide [MeSH Supplementary Concept]
- N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-(4-(4-(2,3-dihydroxypropoxy)phenyl)butyl)guanidine [MeSH Supplementary Concept]
- N-propyl-2,2-diphenyl-2-hydroxyacetamide [MeSH Supplementary Concept]
- PF-06456384 [MeSH Supplementary Concept]
- Ranolazine [MeSH Descriptor]
- SC 1001 [MeSH Supplementary Concept]
- WIN 17317-3 [MeSH Supplementary Concept]
- amiodarone [MeSH Descriptor]
- carbamazepine [MeSH Descriptor]
- dimethylaminoethyl p-butylaminobenzoate [MeSH Supplementary Concept]
- ethyl 4-ethoxybenzoate [MeSH Supplementary Concept]
- fosphenytoin [MeSH Supplementary Concept]
- lysyl-isoleucyl-phenylalanyl-methionyl-lysine [MeSH Supplementary Concept]
- pilsicainide [MeSH Supplementary Concept]
- tetrodotoxin [MeSH Descriptor]
UMLS correspondences (same concept)
- Substance with sodium channel blocker mechanism of action (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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