Preferred Label : Aprepitant;
NCIt synonyms : 5-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-1,2-dihydro-3H-1,2,4-Triazol-3-one;
NCIt related terms : Emend;
NCIt definition : A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity.
Crossing the blood brain barrier, aprepitant binds selectively to the human substance
P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor
binding of endogenous substance P and substance P-induced emesis. This agent has little
or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors.;
Alternative definition : NCI-GLOSS: A drug used together with other drugs to prevent and control the nausea
and vomiting caused by cancer treatment. It is also used to treat nausea and vomiting
after surgery. It is a type of antiemetic and a type of substance P/neurokinin 1 receptor
antagonist.;
UNII : 1NF15YR6UY;
InChIKey : ATALOFNDEOCMKK-OITMNORJSA-N;
CAS number : 170729-80-3;
Drug name : Emend; CINVANTI; Aponvie;
Molecule name : ONO-7436; MK-0869; L-754030; MK 0869;
Chemical formula : C23H21F7N4O3;
ChEBI ID : CHEBI:499361;
Codes from synonyms : CDR0000512781; CDR0000468778; 42;
Origin ID : C49173;
UMLS CUI : C1176306;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
