Preferred Label : Yttrium Y-90 Clivatuzumab Tetraxetan;
NCIt synonyms : 90Y-hPAM4; Yttrium Y 90 Clivatuzumab Tetraxetan; Yttrium (90Y) Clivatuzumab Tetraxetan;
NCIt related terms : yttrium Y 90 DOTA monoclonal antibody HuPAM4;
NCIt definition : A radioimmunoconjugate comprised of the humanized monoclonal antibody clivatuzumab,
directed against the pancreatic cancer antigen MUC1, that is conjugated to the chelating
agent tetraxetan and radiolabeled with the beta-emitting radioisotope Yttrium Y 90.
Yttrium Y 90 clivatuzumab tetraxetan binds to tumor cells expressing MUC1 antigen,
thereby selectively delivering a cytotoxic dose of beta radiation.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of advanced pancreatic cancer.
HuPAM4 is a monoclonal antibody that can locate and bind to pancreatic cancer cells.
It is linked to a radioactive substance called yttrium Y90, which may help kill cancer
cells. Yttrium Y 90 DOTA monoclonal antibody HuPAM4 is a type of radioimmunoconjugate.;
UNII : 2L271110ED;
CAS number : 943976-23-6;
Drug name : hPAM4-Cide;
Molecule name : hPAM4-DOTA; IMMU-107;
Chemical formula : C16H25N5O7.Y;
Codes from synonyms : CDR0000489307;
Origin ID : C48429;
UMLS CUI : C1541526;
Semantic type(s)
- concept_is_in_subset
- has_target
