Preferred Label : Lestaurtinib;
NCIt synonyms : 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocin-1-one,
2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)-;
NCIt related terms : CEP-701;
NCIt definition : An orally bioavailable indolocarbazole derivative with antineoplastic properties.
Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting
in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress
FLT3. (NCI05);
Alternative definition : NCI-GLOSS: A drug being studied in the treatment of acute leukemias and some other
types of cancer. It binds to a protein that is present on the surface of some types
of cancer cells and stops them from dividing. CEP-701 is a type of receptor tyrosine
kinase inhibitor and a type of indolocarbazole alkaloid.;
UNII : DO989GC5D1;
InChIKey : UIARLYUEJFELEN-LROUJFHJSA-N;
CAS number : 111358-88-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 111358-88-4
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : KT-5555; CEP-701; SPM-924;
Chemical formula : C26H21N3O4;
Codes from synonyms : CDR0000386200; 50524; CDR0000559256; 303;
Origin ID : C48402;
UMLS CUI : C1541677;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
