Preferred Label : Ingenol Mebutate;
NCIt synonyms : Ingenol 3-Angelate; Ingenol-3-angelate; 2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a- octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-
methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2Z)-; I3A;
NCIt definition : A selective small-molecule activator of protein kinase C (PKC) isolated from the plant
Euphorbia peplus with potential antineoplastic activity. Ingenol mebutate activates
various protein kinase C (PKC) isoforms, thereby inducing apoptosis in some tumor
cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma
cells. The PKC family consists of signaling isoenzymes that regulate many cell processes
including proliferation, differentiation, and apoptosis.;
UNII : 7686S50JAH;
InChIKey : VDJHFHXMUKFKET-WDUFCVPESA-N;
CAS number : 75567-37-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 75567-37-2
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G-SRS /a ;
Molecule name : PEP-005;
Chemical formula : C25H34O6;
PubMed : 19178487;
Origin ID : C48398;
UMLS CUI : C2825682;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
