Preferred Label : HER-2-neu, CEA Peptides, GM-CSF, Montanide ISA-51 Vaccine;
Obsolete resource : true;
NCIt synonyms : HER-2-neu CEA Peptides GM-CSF Montanide ISA-51 Vaccine;
NCIt definition : A vaccine comprised of HER-2-neu and carcinoembryonic antigen synthetic (CEA) peptides,
combined with the adjuvants granulocyte-macrophage colony stimulating factor (GM-CSF),
and Montanide ISA-51 with potential antineoplastic activity. HER-2-neu, CEA peptides,
GM-CSF, Montanide ISA-51 vaccine may stimulate a cytotoxic T-cell response against
HER-2-neu- and CEA-expressing tumor cells. The GM-CSF adjuvant stimulates the proliferation
of monocytes and monocyte differentiation into macrophages and dendritic cells, immunohematopoietic
elements with important antitumoral functions. Montanide ISA-51, also known as incomplete
Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing
mineral oil with mannide oleate added as a surfactant that non-specifically stimulates
cell-mediated immune responses to antigens.;
Concept status : Obsolete_Concept;
Origin ID : C48392;
UMLS CUI : C1708269;
Semantic type(s)
- chemotherapy_regimen_has_component
- concept_is_in_subset
