Recombinant Granulocyte-Macrophage Colony-Stimulating Factor

Preferred Label : Recombinant Granulocyte-Macrophage Colony-Stimulating Factor;

NCIt synonyms : CSF-GM (Hoechst); Recombinanr Colony-Stimulating Factor 2; Recombinant Colony-Stimulating Factor 2; Colony-Stimulating Factor, Granulocyte-Macrophage; CSF 39300/GM-CSF; GM CSF; GM-CSF (Schering); GM-CSF; Therapeutic Granulocyte-Macrophage Colony-Stimulating Factor;

NCIt related terms : GMCSF;

NCIt definition : A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein cytokine growth factor granulocyte-macrophage colony stimulating factor (GM-CSF). Therapeutic GM-CSF induces the clonal expansion and differentiation of progenitor blood cells and stimulates the cytotoxicity of monocytes and neutrophils, thereby restoring immune function and host antitumor immune responses and stimulating engraftment of transplanted bone marrow tissue. (NCI04);

CAS number : 83869-56-1;

Molecule name : CSF 39300;

NSC code : 613795; 617589; 622183; 643496;

Détails

Origin ID

C1288;

UMLS CUI

C0376563;

Automatic exact mappings (from CISMeF team)
- Granulocyte macrophage colony stimulating factor [LOINC component]
- granulocyte-macrophage colony-stimulating factor [Blood Transfusion thesaurus concept]
Currated CISMeF NLP mapping
- Granulocyte-macrophage colony-stimulating factor, recombinant [SMS substance]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Hematopoietic Stem Cell [NCIt concept]
- Monocyte [NCIt concept]
- Neutrophil [NCIt concept]
chemical_or_drug_affects_gene_product
- GM-CSF Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Hematopoiesis Induction [NCIt concept]
- Immunopotentiation [NCIt concept]
- Myeloid Cell Activation Process [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
has_target
- GM-CSF Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- HER-2-neu, CEA Peptides, GM-CSF, Montanide ISA-51 Vaccine [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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