NCIt definition : A synthetic, orally bioavailable, achiral, tridentate triazole derived from salicylic
acid with iron-chelating activity. Deferasirox chelates iron at a 2:1 (ligand:iron)
ratio. Because of its oral availability and long plasma half-life, this agent may
be superior to desferrioxamine (desferal, DFO), which is orally inactive and has a
short plasma half-life.;
Alternative definition : NCI-GLOSS: A drug used to treat too much iron in the blood caused by blood transfusions.
It is being studied in the treatment of myelodysplastic syndromes (a group of diseases
in which the bone marrow does not make enough healthy blood cells) and other conditions.
Deferasirox binds to extra iron in the blood. The drug and the iron are passed from
the body in urine. It is a type of chelating agent.;
UNII : V8G4MOF2V9;
InChIKey : BOFQWVMAQOTZIW-UHFFFAOYSA-N;
CAS number : 201530-41-8;
Drug name : Exjade; Jadenu;
Chemical formula : C21H15N3O4;
ChEBI ID : CHEBI:49005;
Codes from synonyms : 50595; CDR0000535471; CDR0000514444; 146;
Semantic type(s)