NCIt definition : The mesylate salt form of ziprasidone, a benzothiazolylpiperazine derivative and an
atypical antipsychotic agent with an antischizophrenic property. Ziprasidone mesylate
functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors,
and as an agonist at the 5-HT1A receptor. Ziprasidone mesylate also inhibits the synaptic
reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone
mesylate exerts its antischizophrenic effect is unknown but is potentially mediated
through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also
has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors.;