" /> Ziprasidone - CISMeF





Preferred Label : Ziprasidone;

NCIt synonyms : 2H-Indol-2-one, 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-;

NCIt definition : A benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone also inhibits the synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors.;

UNII : 6UKA5VEJ6X;

InChIKey : MVWVFYHBGMAFLY-UHFFFAOYSA-N;

CAS number : 146939-27-7;

Drug name : Zeldox;

Chemical formula : C21H21ClN4OS;

ChEBI ID : CHEBI:10119;

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05/07/2025


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