NCIt definition : The hydrochloride salt form of thiamine, a vitamin essential for aerobic metabolism,
cell growth, transmission of nerve impulses and acetylcholine synthesis. Upon hydrolysis,
thiamine hydrochloride is phosphorylated by thiamine diphosphokinase to form active
thiamine pyrophosphate (TPP), also known as cocarboxylase. TPP is a coenzyme for many
enzymatic activities involving fatty acid, amino acid and carbohydrate metabolism.;