Preferred Label : Hydrocortisone Butyrate;
NCIt synonyms : 11-beta,17-alpha,21-Trihydroxy-4-pregnene-3,20-dione 17-alpha-butyrate;
NCIt definition : The butyrate salt form of hydrocortisone, a synthetic glucocorticoid receptor agonist
with antiinflammatory, antipruritic and vasoconstrictive effects. Binding and activation
of the glucocorticoid receptor results in the activation of lipocortin that in turn
inhibits cytosolic phospholipase A2. Lack of phospholipase A2 prevents the release
of arachidonic acid, precursor for inflammatory mediator prostaglandins and leukotrienes,
from the cell membrane. Secondly, mitogen-activated protein kinase (MAPK) phosphatase
1 is induced, thereby leading to dephosphorylation and inactivation of Jun N-terminal
kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional
activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription
of cyclooxygenase 2, which is essential for prostaglandin production.;
UNII : 05RMF7YPWN;
InChIKey : BMCQMVFGOVHVNG-TUFAYURCSA-N;
CAS number : 13609-67-1;
Chemical formula : C25H36O6;
ChEBI ID : CHEBI:31674;
Origin ID : C48022;
UMLS CUI : C0352536;
Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
