NCIt definition : The edisylate salt form of prochlorperazine, a derivative of phenothiazine with antipsychotic
and antiemetic properties. Prochlorperazine edisylate blocks postsynaptic dopamine
receptors in cortical and limbic areas of the brain, thereby preventing the excess
of dopamine in the brain. This leads to a reduction in psychotic symptoms, including
hallucinations and delusions. Prochlorperazine edisylate appears to exert its antiemetic
activity by blocking the dopamine and histamine receptors in the chemical trigger
zone (CTZ) in the brain, thereby relieving nausea and vomiting.;