NCIt definition : The hydrochloride salt of a synthetic nitroimidazole derivative with antiprotozoal
and antibacterial activities. Although its mechanism of action is not fully elucidated,
un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is
subsequently reduced by low-redox potential electron-transport proteins to an active,
intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting
DNA synthesis and bacterial cell growth.;
Alternative definition : NCI-GLOSS: A drug that is used to treat infection and is being studied in the treatment
of cancer. It is type of antibacterial, antiprotozoal, and anthelmintic.;