Lidocaine Hydrochloride

Preferred Label : Lidocaine Hydrochloride;

NCIt synonyms : 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide Monohydrochloride;

NCIt related terms : Xylocitin; Xylotox; Xylocaine;

NCIt definition : The hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na . This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.;

UNII : V13007Z41A;

InChIKey : YECIFGHRMFEPJK-UHFFFAOYSA-N;

CAS number : 6108-05-0;

Drug name : Xylotox; Xylocitin; Xylocaine;

Chemical formula : C14H22N2O.HCl.H2O;

ChEBI ID : CHEBI:60791;

Codes from synonyms : NSC0040030;

Details

Origin ID

C48000;

UMLS CUI

C0546869;

Automatic exact mappings (from CISMeF team)
- Lidocaine [ICD-11 Extension code]
- Lidocaine [ICHI extension code]
- lidocaine [MeSH Descriptor]
- lidocaine [ATC Code]
- lidocaine [ATC Code]
- lidocaine [MeSH concept]
- lidocaine [ATC Code]
- lidocaine [ATC Code]
- lidocaine [ATC Code]
- lidocaine [ATC Code]
- lidocaine [Radlex concept]
- lidocaine [ATC Code]
- lidocaine [EMDN type]
Currated CISMeF NLP mapping
- Lidocaine hydrochloride [Substance BNPC]
- Lidocaine hydrochloride [SMS substance]
- Lidocaine hydrochloride (substance) [SNOMED CT concept]
- lidocaine hydrochloride [MeSH concept]
- lidocaine hydrochloride [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Lidocaine [LOINC component]
- Lidocaine (substance) [SNOMED CT concept]
- lidocaine [MeSH Descriptor]
- lidocaine [Substance BNPC]
- lidocaine [SNOMED Notion]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Lidocaine [NCIt concept]
is_salt_form_of
- Lidocaine [NCIt concept]

Keyword's position in hierarchy(ies) :

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