Estramustine Phosphate Sodium

Preferred Label : Estramustine Phosphate Sodium;

NCIt synonyms : Estramustine 17-(Dihydrogenphosphate) Disodium Salt;

NCIt related terms : Leo 299; Estramustine phosphate; Estracyt; Estramustine sodium phosphate;

NCIt definition : The orally available disodium salt, monohydrate, of estramustine phosphate, a synthetic molecule that combines estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects.;

UNII : 75F375MT2N;

InChIKey : OAIHMBRTKDWZQG-WFVUJJAZSA-L;

CAS number : 52205-73-9;

Drug name : Estracyt; Emcyt;

Molecule name : Ro-21-8837/001; Leo-299;

Chemical formula : C23H30Cl2NO6P.2Na;

NSC code : 89199;

ChEBI ID : CHEBI:31562;

Codes from synonyms : NSC0089199; NSC0702294;

Details

Origin ID

C480;

UMLS CUI

C0014922;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Estramustine phosphate sodium (substance) [SNOMED CT concept]
- estramustine phosphate sodium [MeSH concept]
Validated automatic mappings to NTBT
- Estramustine phosphate [SMS substance]
- Estramustine phosphate (substance) [SNOMED CT concept]
- estramustine [MeSH Descriptor]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Estramustine [NCIt concept]
has_target
- Tubulin [NCIt concept]
is_component_of_chemotherapy_regimen
- Cisplatin/Cyclophosphamide/Estramustine/Fluorouracil Regimen [NCIt concept]
is_salt_form_of
- Estramustine [NCIt concept]

Keyword's position in hierarchy(ies) :

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