" /> Estramustine - CISMeF





Preferred Label : Estramustine;

NCIt synonyms : estradiol 3-bis(2-chloroethyl)carbamate; estra-1,3,5(10)triene-317beta-diol 3-[N,N-bis-(2-chloroethyl)carbamate]; 17beta-(estra-1,3,5(10)-triene-3,17-diol 3-(bis(2-chloroethyl)carbamate));

NCIt related terms : Estradiol 3-[bis(2-chloroethyl)carbamate];

NCIt definition : A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. (NCI04);

Alternative definition : NCI-GLOSS: A combination of the hormone estradiol (an estrogen) and nitrogen mustard (an anticancer drug). Used in the palliative therapy of prostate cancer.;

UNII : 35LT29625A;

InChIKey : FRPJXPJMRWBBIH-RBRWEJTLSA-N;

CAS number : 2998-57-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2998-57-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : Leo 275; RO 21-8837;

Chemical formula : C23H31Cl2NO3;

NSC code : 89201;

ChEBI ID : CHEBI:4868;

Codes from synonyms : NSC0089201; CDR0000045195; 200;

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15/05/2024


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