NCIt definition : The hydrochloride salt of fluphenazine, a phenothiazine with antipsychotic activity
and potential antineoplastic activity. Fluphenazine blocks postsynaptic dopamine D2
receptors in the limbic system, cortical system and basal ganglia, resulting in a
reduction of schizophrenia-associated hallucinations and delusions. In addition, as
a serotonin antagonist, this agent may inhibit lymphocyte and myeloma cell proliferation
by blocking 5-hydroxytrptamine type 1B (5-HT type 1B) receptors for serotonin.;
Alternative definition : NCI-GLOSS: A drug that is used to treat mental and emotional disorders and is being
studied in the treatment of multiple myeloma. Fluphenazine hydrochloride may stop
tumor growth by keeping myeloma cells from dividing and causing them to die. It is
a type of antipsychotic.;