Demeclocycline

Preferred Label : Demeclocycline;

NCIt synonyms : 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide;

NCIt definition : A semi-synthetic, broad-spectrum naphthacene antibiotic produced by the bacterium Streptomyces aureofaciens. Demeclocycline binds to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline also inhibits the effect of vasopressin on the renal tubules, thereby causing diuresis.;

UNII : 5R5W9ICI6O;

InChIKey : FMTDIUIBLCQGJB-SEYHBJAFSA-N;

CAS number : 127-33-3;

Chemical formula : C21H21ClN2O8;

ChEBI ID : CHEBI:4392;

Détails

Origin ID

C47980;

UMLS CUI

C0011276;

Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Demeclocycline [ICD-11 Extension code]
- Demeclocycline [LOINC component]
- Demeclocycline (substance) [SNOMED CT concept]
- Product containing demeclocycline (medicinal product) [SNOMED CT concept]
- demeclocycline [ATC Code]
- demeclocycline [ATC Code]
- demeclocycline [Substance BNPC]
- demeclocycline [MeSH concept]
- demeclocycline [MeSH Descriptor]
- demeclocycline [SNOMED Notion]
Validated automatic mappings to BTNT
- declomycin [MeSH concept]
- demeclocycline [ATC Code]
- demeclocycline [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Demeclocycline Calcium [NCIt concept]
- Demeclocycline Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Demeclocycline Calcium [NCIt concept]
- Demeclocycline Hydrochloride [NCIt concept]

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