Preferred Label : Demeclocycline Hydrochloride;
NCIt synonyms : 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide
Monohydrochloride;
NCIt related terms : Declomycin;
NCIt definition : The hydrochloride salt of demeclocycline, a broad-spectrum, tetracycline derivative
exhibiting antimicrobial, aquaretic and chelating activities. In bacteria, demeclocycline
binds reversibly to the 30S ribosomal subunit and blocks the binding of aminoacyl-tRNA
to the A-site of the mRNA-ribosome complex, resulting in the inhibition of protein
synthesis and bacterial cell death. In mammals, this agent interferes with the action
of antidiuretic hormone (ADH) at the level of the renal collecting tubule, resulting
in aquaresis. In addition, demeclocycline, which like other tetracyclines chelates
calcium in bone and exhibits a yellow fluorescence under ultraviolet (UV) light, may
be used as a fluorescent bone-labeling agent in bone histomorphometry.;
Alternative definition : NCI-GLOSS: A substance being studied as a way to detect bone growth in patients receiving
bisphosphonates (a type of drug used to treat bone pain caused by some types of cancer)
for breast cancer. It binds to newly formed bone. A biopsy is done and bone growth
is measured using a special microscope. Declomycin is a type of tetracycline antibiotic
and a type of bone-labeling agent.;
UNII : 29O079NTYT;
InChIKey : GVSJQNRGSCOSNJ-KBHRXELFSA-N;
CAS number : 64-73-3;
Drug name : Declomycin;
Chemical formula : C21H21ClN2O8.HCl;
ChEBI ID : CHEBI:59725;
Codes from synonyms : CDR0000644735; CDR0000644736;
Origin ID : C28975;
UMLS CUI : C0282125;
Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
