NCIt definition : The sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin
with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding
proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation
of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial
cell wall strength and rigidity, which results in the weakening of the bacterial cell
wall and cell lysis.;