Cefazolin - CISMeF

Preferred Label : Cefazolin;

NCIt synonyms : (6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid;

NCIt definition : A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.;

UNII : IHS69L0Y4T;

CAS number : 25953-19-9;

Chemical formula : C14H14N8O4S3;

ChEBI ID : CHEBI:474053;

Details

Origin ID

C28913;

UMLS CUI

C0007546;

Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Cefazolin [ICD-11 Extension code]
- Cefazolin (substance) [SNOMED CT concept]
- Product containing cefazolin (medicinal product) [SNOMED CT concept]
- ceFAZolin [LOINC component]
- cefazolin [ATC Code]
- cefazolin [Substance BNPC]
- cefazolin [MeSH concept]
- cefazolin [MeSH Descriptor]
- cephazolin [SNOMED Notion]
Validated automatic mappings to BTNT
- cefazolin [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Cefazolin Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Cefazolin Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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