Topiramate - CISMeF

Preferred Label : Topiramate;

NCIt synonyms : beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, Sulfamate;

NCIt definition : A sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.;

UNII : 0H73WJJ391;

InChIKey : KJADKKWYZYXHBB-XBWDGYHZSA-N;

CAS number : 97240-79-4;

Drug name : Topamax;

Chemical formula : C12H21NO8S;

ChEBI ID : CHEBI:63631;

Details

Origin ID

C47764;

UMLS CUI

C0076829;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing topiramate (medicinal product) [SNOMED CT concept]
- Topiramate [MeSH Descriptor]
- Topiramate [LOINC component]
- Topiramate (substance) [SNOMED CT concept]
- topiramate [ATC Code]
- topiramate [Substance BNPC]
- topiramate [MeSH concept]
Validated automatic mappings to BTNT
- topiramate [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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