Ticlopidine Hydrochloride

Preferred Label : Ticlopidine Hydrochloride;

NCIt synonyms : Ticlodone; Ticlodix; Panaldine; 5-(o-Chlorobenzyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridinium Chloride; Thieno(3,2-c)pyridine, 5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-, Hydrochloride;

NCIt definition : The hydrochloride salt form of ticlopidine, a thienopyridine derivative with anticoagulant property. Ticlopidine hydrochloride irreversibly inhibits adenosine-diphosphate (ADP)-induced platelet-fibrinogen binding by binding to the glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. Inhibition of the receptor activation causes the inhibition of adenylyl cyclase, results in decreased levels of cyclic adenosine monophosphate and thereby interferes with platelet membrane function and subsequent, platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time.;

UNII : A1L4914FMF;

InChIKey : MTKNGOHFNXIVOS-UHFFFAOYSA-N;

CAS number : 53885-35-1;

Drug name : Ticlid;

Chemical formula : C14H14ClNS.HCl;

ChEBI ID : CHEBI:9589;

Details

Origin ID

C47756;

UMLS CUI

C0000598;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 5-(o-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridinium chloride [Substance BNPC]
- Ticlopidine Hydrochloride [MeSH concept]
- Ticlopidine hydrochloride (product) [Inactive SNOMED CT concept]
- Ticlopidine hydrochloride (substance) [SNOMED CT concept]
Validated automatic mappings to NTBT
- Ticlopidine [SMS substance]
- Ticlopidine (substance) [SNOMED CT concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Ticlopidine [NCIt concept]
is_salt_form_of
- Ticlopidine [NCIt concept]

Keyword's position in hierarchy(ies) :

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