Preferred Label : Tacrine Hydrochloride;
NCIt synonyms : Tenakrin; Hydroaminacrine; 1,2,3,4-tetrahydro-9-acridinamine Monohydrochloride Monohydrate;
NCIt definition : The hydrochloride salt form of tacrine, an aminoacridine derivative with cognitive
stimulating property. Although the mechanism of action has not been fully elucidated,
tacrine hydrochloride may bind reversibly to cholinesterase, acetylcholinesterase
as well as butyrylcholinesterase, thereby decreasing the breakdown of acetylcholine,
and prolonging synaptic actions as well as increased release of acetylcholine. In
addition, this agent inhibits monoamine oxidase (MAO) and may inhibit the reuptake
of catecholamines and serotonin. Finally, a novel mechanism of action studied in animal
models suggests tacrine to attenuate the production of interleukin-1beta in the hippocampus
and blood, thereby producing central and peripheral anti-inflammatory effects that
may play a role in Alzheimer's disease.;
UNII : 4966RNG0BU;
InChIKey : ZUFVXZVXEJHHBN-UHFFFAOYSA-N;
CAS number : 1684-40-8;
Drug name : Cognex;
Chemical formula : C13H14N2.HCl;
NSC code : 72108;
Origin ID : C47742;
UMLS CUI : C0771182;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
